Our study aims to show whether the administration of Fibroblast Growth Factor-2 (FGF2) and ozone against neuron-damaging hypoxia-ischemia has any neuroprotective effects in rats exposed to experimental cerebral ischemia-reperfusion. 6 groups were created with each group containing 10 rat that 7d old male Wistar rats. The first group, which was the Sham group, was the one in which a neck dissection was performed while ischemia was not caused. 2nd group, carotid arteries were linked, hypoxia was induced in order to cause hypoxia-ischemia (HI), which is done all groups except sham. The other groups were the ones with 10 µl/ml and 20 µl/ml FGF2 administered. The last groups were the ones with 25 ?g/ml and 50 ?g/ml ozone administered, routine tissue follow-up procedures were carried out and stained with hematoxylin and eosin stain, and inflammation, eosinophilic cytoplasm, edema in the cerebral cortex, vascular congestion and necrobiotic-necrotic changes were scored and evaluated. In light microscope revealed moderate-to-severe eosinophilic cytoplasm and necrobiotic changes in the HI group when compared to the Sham group and the 20 µl/ml FGF2 group among others. Significant differences in the criteria of inflammation, vascular congestion and edema in the cerebral cortex was detected between the same groups. Kruskal-Wallis test was used for intergroup comparison resulted in a statistically significant difference between all of the study groups (p< 0.05). In our study, morphological recovery was observed depending on the different doses of FGF2 and ozone used to protect the neurons, were fund to be statistically significant.