In this study with utilized CLO model, was investigated the climate comfort in Isfahan province and localizing it for tourists. Thus, the data was collected from 22 synoptic stations, inside and around this province. The results revealed that in Isfahan province, for January, two climate ranges with very cold and cold weather clothing, in December and February, three climate ranges including very cold, cold, and comfortable/light clothing, for March, October and November, two climate ranges with cold weather and comfortable clothing, in April, three climate ranges including cold weather, comfortable, and summer clothing, for May, two climate ranges with comfortable and summer clothing, and in June, July, August, and September three climate ranges including comfortable, summer, and tropical clothing were required in order to achieve climate comfort for tourists. Very cold weather clothing includes long underwear, coat, thick pants, gloves, woolen socks, winter scarf, and hat for women; and long underwear, thick suit, coat, gloves, woolen socks, winter scarf, and hat are used for men. Cold weather clothing also covers long cotton underwear, dress, pants, head scarf or winter scarf, sweatshirt, jacket, and thick socks for women; and long cotton underwear, suit, overcoat, hat, and thick socks are men’s clothing. Comfortable clothing contains dress, pants, head scarf or scarf, shoes, and socks for women; for men, shirt, t-shirt, pants, shoes, and socks. Summer clothing for women is cotton dress, long cotton pants, and cotton headscarf or scarf and summer shoes; for men, we suggest cotton shirt or t-shirt, long cotton shirt, and summer shoes. Tropical clothing includes linen dress, light long pants, cotton headscarf or scarf, and sandals for women; this type of clothing for men contains short-sleeved cotton shirt, light long pants, and sandals. These clothing articles were offered to tourists in Isfahan province according to the national culture in Iran to achieve climate comfort.